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Epoxyquinone G109 (racemic)

N-SMase inhibitor
 
ALX-270-341-M002 2 mg 234.00 USD
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Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase).

Product Specification

Formula:C18H27NO4
 
MW:321.4
 
CAS:163972-12-1 ((+)-enantiomer)
 
Purity:≥98%
 
Identity:Identity determined by MS, 1H- and 13C-NMR.
 
Appearance:Pale yellow powder.
 
Solubility:Soluble in DMSO or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
270-341
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270-341

Product Literature References

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction: D.A. Taylor-Fishwick, et al.; Diabetologia 58, 549 (2015), Abstract;
Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways: A. Erdreich-Epstein, et al.; Blood 105, 4353 (2005), Abstract;
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001), Abstract;

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