Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase).
Product Specification
| Formula: | C18H27NO4 |
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| MW: | 321.4 |
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| CAS: | 163972-12-1 ((+)-enantiomer) |
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| Purity: | ≥98% |
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| Identity: | Identity determined by MS, 1H- and 13C-NMR. |
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| Appearance: | Pale yellow powder. |
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| Solubility: | Soluble in DMSO or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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Product Literature References
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction: D.A. Taylor-Fishwick, et al.; Diabetologia
58, 549 (2015),
Abstract;
Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways: A. Erdreich-Epstein, et al.; Blood
105, 4353 (2005),
Abstract;
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem
2, 141 (2001),
Abstract;
