Cell permeable, selective and reversible PPARγ antagonist. Has been shown to inhibit the agonist activity of rosiglitazone (Prod. No. ALX-350-125) in a dose-dependent manner (IC50=31.9µM).
Product Details
| Alternative Name: | H-WE-OH, G3335 |
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| Formula: | C16H19N3O5 |
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| MW: | 333.3 |
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| CAS: | 36099-95-3 |
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| Purity: | ≥97% |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator activated receptors: N. B. Mettu, et al.; Mol. Endocrinol.
21, 2361 (2007),
Abstract;
Full Text
The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation: F. Ye, et al.; Chembiochem.
7, 74 (2006),
Abstract;
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