Selective, biotin-labelled ligand of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.
Product Specification
| Alternative Name: | Pam3CSK4 (Aca-Aca-Biotin) . 2TFA, (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH Aca-Aca-Biotin) . 2TFA |
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| Formula: | C103H192N14O17S2 . 2C2HF3O2 |
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| MW: | 1962.9 . 228.1 |
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| Formulation: | Lyophilized. |
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| Quality Control: | Confirmed by ESI-MS. |
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| Appearance: | Colorless powder. |
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| Solubility: | Soluble in water, saline or aqueous buffers at pH <7.5. |
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| Reconstitution: | Reconstitute with water to 1mg/ml stock solution. Through the use of either a homogeniser or sonicator, a homogenous solution can be prepared. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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Product Literature References
Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases: E.G. Stefanich, et al.; Biochem. Pharmacol.
152, 224 (2018),
Abstract;
The role and regulation of Moraxella catarrhalis-induced human beta-defensin 3 expression in human pulmonary epithelial cells: H. Haarmann, et al.; Biochem. Biophys. Res. Commun.
467, 46 (2015),
Application(s): Cell Culture,
Abstract;
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