Alternative Name: | KLK6, Neurosin, Protease M |
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Clone: | F7 |
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Host: | Mouse |
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Isotype: | IgG |
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Immunogen: | Recombinant protein corresponding to aa 17-244 of human kallikrein-6 (His-tagged). |
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UniProt ID: | Q92876 |
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GenBank ID: | 30582543 |
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Gene/Protein Identifier: | 5653 (Gene ID) |
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Species reactivity: | Human
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Applications: | ELISA, WB
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Application Notes: | Detects a band of ~27kDa by Western blot. |
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Purity Detail: | Protein G-affinity purified. |
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Formulation: | Liquid. In 1X PBS, pH 7.4, containing 10% glycerol and 0.05% sodium azide. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins, including KLK6, are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded KLK6 enzyme is regulated by steroid hormones. In tissue culture, KLK6 has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. |
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Regulatory Status: | RUO - Research Use Only |
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