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Cell Signaling and Signal Transduction










Understanding Pathways

From receptor- or ion channel-mediated transmission of signals across the cell membrane, to amplification through second messenger systems, kinase or proteolytic cascades or other post-translational modifications, Enzo Life Sciences offers an unrivaled catalog of cutting-edge tools for signal transduction research. From receptor to effector a portfolio of assays, recombinant enzymes & substrates, small molecule reagents and antibodies is available to facilitate thorough characterization of your pathway of interest.

 

Solutions For Wnt Pathway Screening

High-throughput Assays for Canonical Wnt Pathway Analysis

Since the discovery of the Wnt gene over 30 years ago as the Int1 proto-oncogene involved in the pathology of Mouse Mammary Tumor Virus (MMTV), Wnt expression and signal transduction have been identified as critical components in regulating embryogenesis, cell proliferation, and bone, glucose, and lipid metabolism. Perturbations in Wnt expression, surface receptors, signaling partners (including β-catenin and GSK-3β), and the battery of Wnt-regulated genes (collectively the canonical Wnt pathway) are known to manifest in a variety of clinically relevant disease states, including cancer, osteoporosis, cardiovascular disease, diabetes, and neurodegeneration.



 

Screen Wnt Pathway Activators & Inhibitors

Leading Light™ Wnt Reporter Assay
Development of Wnt pathway modulating drugs requires the ability to rapidly screen the effect of novel or repurposed compounds and biological therapeutics on the expression of Wnt-regulated genes, and confirmation of such effects by related changes in key signaling components. Together, the Leading Light™ Wnt Reporter Assay and Screen-Well® Wnt Pathway Library facilitate high-throughput analysis of Wnt-related signaling.

Quantify Critical Wnt Pathway Proteins

Sensitive Wnt Pathway ELISA Kits
Obtain fully quantitative data with immunometric detection of β-Catenin, total and phosphorylated GSK-3β, and DKK-1 in human, mouse and rat samples.

Highly Characterized Wnt Related Proteins & Antibodies
Enzo offers a wide selection of high-quality reagents for analysis of Wnt related signal transduction, including purified proteins and thoroughly validated monoclonal and polyclonal antibodies.

Cyclic Nucleotide ELISA Kits

Enzo Life Sciences offers the most sensitive and complete colorimetric ELISA kits for quantification of intracellular or extracellular cAMP or cGMP in a variety of sample types.

  • Sensitive – optional acetylation protocol increases sensitivity 10-fold (0.039 pmol/ml)
  • Trusted – regularly cited in peer-reviewed publications
  • Simple – efficient and well-established sample handling protocols
  • Reliable – consistent lot-to-lot performance

 

TNF & TNF Receptor Superfamily

High-quality Enhanced TNF Ligands Deliver Consistent Results

Our high-activity MegaCD40L™ is the highest-purity, most stable on the market, and is just one of many reliable enhanced TNF ligands for immune activation studies.


Experience the Purity, Sensitivity, and Reproducibility of Enzo TNF Superfamily Products

  • High-purity ligands & receptors, including enhanced activity Mega™Ligands
  • Over 150 worry-free antibodies to TNF ligands & receptors
  • High-sensitivity, easy-to use ELISA kits for soluble factors
 

Inflammation & Immunity

Efficient Analysis of Innate and Adaptive Immune Responses


 

Calcium Mobilization Assays

Utilizing the brightest and most sensitive fluorescent Ca2+ indicator, FluoForte™ Calcium Assay kit provides much higher signal intensity and the largest assay window on the market. Enzo Life Sciences' homogeneous fluorescence-based assay kit detects calcium mobilization across a broad spectrum of biological targets. Easy-to-use protocol does not require a wash step or exogenous addition of a quencher dye, which could adversely affect receptor-ligand interaction kinetics. The assay can be performed in a convenient 96-well or 384-well microplate format and easily adapts to automation.


 

Related Literature and Documents

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