Comprehensive Tools for Interpreting Immunological Responses

Maintaining the proper balance between immune activation and suppression is critical for physiological functioning of the innate and adaptive immune system. Disruption of this equilibrium leads to immunological disorders including autoimmune diseases, hypersensitivities, and immune deficiency. Enzo Life Sciences provides a comprehensive portfolio of products to detect and modulate the complex processes of immunological disease.

Immuno-oncology, also known as cancer immunotherapy, refers to the use of a person’s own immune system for the treatment of cancer. Research in the field includes:

• Targeting immune tolerance via co-inhibitory immune checkpoints
• Enhancing immune responses by costimulatory checkpoint pathways

Toll-like Receptors

Providing the purest ligands for recognition by pattern recognition receptors.

TLRGRADE® LPS & Lipid A Reagents

• Ultrapure (≥99.9%)
• Sterile, ready-to-use liquid formulation
• No hazardous handling

Worry-Free Antibodies

Enzo offers over 50 TLR antibodies validated for flow cytometry and microscopy applications.

Native Bacterial and Viral Antigens

Optimized Expression Systems Deliver Superior Antigenicity
We offer a broad range of native state bacterial and viral antigens for vaccine research and in vitro diagnostics markets. Purified native protein or production in the latest mammalian expression systems ensure that the resultant antigens are expressed to a high level, are in their native folded state, and possess all relevant post-translational modifications.

• Higher specificity and sensitivity
• Minimal lot-to-lot variation
• Reproducible scale-up for bulk quantities
• Lyophilized format for extended shelf-life

Cytokine & Eicosanoid

Cytokines are secreted signaling molecules that mediate and regulate immunity, inflammation and many developmental processes during embryogenesis. Cytokines can have pleiotropic, overlapping, and sometimes contradictory functions, and also play an important role in angiogenesis  and cancer. Eicosanoids are a group of biologically active oxygenated unsaturated fatty acids derived from arachidonic acid by the action of cyclooxygenases, lipoxygenases, and cytochrome P450 mono-oxygenases. The eicosanoid family includes prostaglandins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and lipoxins. Eicosanoids have been shown to enhance, as well as attenuate inflammation and have also been linked to carcinogenesis.

Enzo’s portfolio of ELISA kits for cytokines and eicosanoids features:

• Over 100 sensitive ELISAs for quantifying cytokines and eicosanoids
• Over 20 years of ELISA development and manufacturing experience
• Widely cited in peer-reviewed publications
• Low cost-per-test, high-throughput, multi-plate pack sizes available
• Time-saving, easy-to-use kits with results in less than 3 hours

C-Reactive Protein

C-Reactive Protein (CRP) is a pentraxin family protein that is widely used as a biomarker for systemic inflammation and tissue injury. Its primary role in innate immunity is to function as an opsonin for pathogens via activation of the complement pathway and through binding to Fc gamma receptors. CRP has been shown to play an important role in a variety of pathological pathways.

CRP, ELISA Kit

• Sensitive assay detects as little as 12.685 ng/ml in serum and plasma
• Highly specific with negligible reactivity to other family members
• Rapid results in just 1.5 hours

Typical standard curve shows broad range of detection

Enzo Life Sciences offers a broad range of antibodies for use in all areas of immunology. Many are validated for use in key applications such as flow cytometry, immunohistochemistry, immunoprecipitation and Western blotting. Every antibody is backed by our Worry-free Antibody Trial Program, allowing you to evaluate any of our antibodies of interest for your specific application or species without risk.

MBL (Mannan-Binding Lectin) is a carbohydrate-binding protein produced in the liver and secreted into the blood. The protein plays a key factor in innate immunity, functioning as a player in the complement activation cascade and defending the body against invading microorganisms (bacteria, viruses, protozoa and fungi).