Although the mechanism may vary from one class of neurodegenerative disease to another, the principle pathology of AD, PD, HD, and ALS are similar: the cell’s defense mechanisms against protein aggregation (i.e., molecular chaperones, protein degradation & recycling pathways) become overwhelmed, leading to structural defects, apoptosis, and ensuing cognitive defects associated with loss or impairment of neural cell function.
A no-transfection quantitative assay for measuring autophagy in live cells.
Quantify Aggresomes and Inclusion Bodies by Flow Cytometry
The definitive collection of Stressgen® ELISA Kits and reagents for molecular chaperones & oxidative stress.
αB-Crystallin
Calnexin
Calreticulin
DNA Damage (8-OHdG)
HSP25/27
HSP40
HSP60
HSP70 & HSC70
HSP90
Grp75
Grp94
Heme Oxygenase
Superoxide Dismutase (SOD)
Molecular-rotor dye yields robust, quantitative detection of aggregated protein.
Profile Autophagy Without Transfection
97 ready to screen compounds with defined autophagy-inducing or –inhibiting activity
A real-time mitochondrial membrane potential assay with superior sensitivity.
Detect Mitochondrial Toxicity With 10X More Sensitivity Than JC-1
