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NGAL (human), (recombinant)

 
ENZ-PRT113-1000 1 ml 214.00 USD
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Product Specification

Alternative Name:Neutrophil gelatinase-associated lipocalin, Lipocalin 2, Siderocalin, Oncogene 24p3
 
Source:Produced in E. coli.
 
UniProt ID:P80188
 
Concentration:1000pg/ml
 
Formulation:Liquid. In 0.01 M phosphate buffer, pH 7.4, containing 0.14 M NaCl, 0.5% BSA, 0.5% Tween 20, 0.0016% Phenol red, and 0.1% Proclin 950.
 
Applications:ELISA
 
Shipping:Blue Ice Not Frozen
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
Scientific Background:Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophil lipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilic molecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single protein chain monomers, which form dimers and small amounts of higher oligomers, as well as complexes with matrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by acute kidney injury.
 

Product Literature References

The Monomer is the Major Form of NGAL in Urine and Plasma in Severe Sepsis: Bangert, et al.; J. Am. Soc. Nephrol. 24, 368A (2013),

General Literature References

Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases: Nielsen, et al.; Gut 38, 414 (1996),
Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase: Kjeldsen, et al.; J. Biol. Chem. 268, 10425 (1993),

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