Liquid. In 0.01 M phosphate buffer, pH 7.4, containing 0.14 M NaCl, 0.5% BSA, 0.5% Tween 20, 0.0016% Phenol red, and 0.1% Proclin 950.
Applications:
ELISA
Shipping:
Blue Ice Not Frozen
Short Term Storage:
+4°C
Long Term Storage:
+4°C
Scientific Background:
Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophil lipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilic molecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single protein chain monomers, which form dimers and small amounts of higher oligomers, as well as complexes with matrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by acute kidney injury.
Regulatory Status:
RUO - Research Use Only
General Literature References
Assessment of candidate biomarkers of drug-induced hepatobiliary injury in
preclinical toxicity studies: Adler, et al.; Toxicology Letters 196, 1 (2010),
Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary
biomarker for ischemic renal injury: Mishra, et al.; J. Am. Soc. Nephrol. 14, 2534 (2003),
NGAL Expression in Kidney of Spontaneously Hypertensive Rats (SHR) Treated
with Doxorubicin (DXR) Alone or Combined with Dexrazoxane (DRZ): Zhang, et al.; Presented at Tox Expo 2009
Ultra sensitive (1.279 pg/ml) ELISA kit, enabling reduced input sample and matrix interference, for the quantification of KIM-1, an early biomarker for kidney injury or disease.