Domoic acid

Kainate receptor agonist



BML-EA117-0001	1 mg	124.00 USD

Replaces Prod. #: ALX-550-152

Glutamate/kainate excitatory amino acid agonist with highest affinity for the kainate receptor of all known kainic acid analogs. Causes confusion and memory loss which resembles anterograde memory loss associated with Alzheimers disease.

Product Specification

Alternative Name:	[2S-[2α,3β,4β(1Z,3E,5R)]]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic acid

Formula:	C₁₅H₂₁NO₆

MW:	311.3

Purity:	≥98% (TLC)

Appearance:	White to off-white solid.

CAS:	14277-97-5

MI:	14: 3417

Source/Host:	Isolated from Nitzschia pungens f. multiseries.

Solubility:	8mg/ml soluble in water.

Long Term Storage:	-20°C

Use/Stability:	Stock solutions are stable for up to 3 months when stored at -20°C.

Hazard:	HARMFUL.

Background / Technical Information:	Please click here for the comprehensive product data sheet.

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Product Literature References

Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid: A.C. Scallet, et al.; Neurotoxicol. Teratol. 27, 745 (2005), Abstract;

The activation of glutamate receptors by kainic acid and domoic acid: D.R. Hampson & J.L. Manalo; Nat. Toxins 6, 153 (1998), Review, Abstract;

Domoic acid induced release of [3H]GABA in cultured chick retina cells: M. Alfonso, et al.; Neurochem. Int. 24, 267 (1994), Abstract;

Domoic acid inhibits adenylate cyclase activity in rat brain membranes: M.S. Nijjar & B. Grimmelt; Mol. Cell. Biochem. 136, 105 (1994), Abstract;

Evidence for hybrid NMDA/kainate receptors from protein reconstitution studies and expression of vertebrate CNS RNAs in Xenopus oocytes: P.N. Usherwood & E.A. Barnard; Comp. Biochem. Physiol. [C] 103, 19 (1992), Abstract;

Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain: D.R. Hampson, et al.; Eur. J. Pharmacol. 218, 1 (1992), Abstract;

Parenteral domoic acid impairs spatial learning in mice: B.F. Petrie, et al.; Pharmacol. Biochem. Behav. 41, 211 (1992), Abstract;

Pharmacology of systemically administered domoic acid in mice: R.A. Tasker, et al.; Can. J. Physiol. Pharmacol. 69, 378 (1991), Abstract;

Transfer constants for blood-brain barrier permeation of the neuroexcitatory shellfish toxin, domoic acid: E. Preston & I. Hynie; Can. J. Neurol. Sci. 18, 39 (1991), Abstract;

Domoic acid: a dementia-inducing excitotoxic food poison with kainic acid receptor specificity: G.R. Stewart, et al.; Exp. Neurol. 110, 127 (1990), Abstract;

Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus: G. Debonnel, et al.; Can. J. Physiol. Pharmacol. 67, 29 (1989), Abstract;

Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island: P. Wright, et al.; Can. J. Chem. 67, 481 (1989),

A kainic acid receptor from frog brain purified using domoic acid affinity chromatography: D.R. Hampson & R.J. Wenthold; J. Biol. Chem. 263, 2500 (1988), Abstract; Full Text

The primary afferent depolarizing action of kainate in the rat: S.G. Agrawal & R.H. Evans; Br. J. Pharmacol. 87, 345 (1986), Abstract;

Structure-activity relations of excitatory amino acids on frog and rat spinal neurones: T.J. Biscoe, et al.; Br. J. Pharmacol. 58, 373 (1976), Abstract;