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Toll-like receptor 10 (human) monoclonal antibody (3C10C5)

 
ALX-804-610-C100 100 µg 287.00 USD
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Replaces Prod. #: ALX-804-407

Product Specification

Alternative Name:TLR10, CD290
 
Clone:3C10C5
 
Host:Mouse
 
Isotype:IgG1 κ
 
Immunogen:Synthetic peptide corresponding to aa20-474 (extracellular domain) of human TLR10.
 
UniProt ID:Q9BXR5
 
Species reactivity:Human
 
Applications:Flow Cytometry
 
Application Notes:Flow Cytometry: Suitable for cell surface FC.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
 
Use/Stability:Stable for at least 6 months when stored at +4°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms. TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kappa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes. TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.
 

Product Literature References

Reactive Oxygen Species Enhance TLR10 Expression in the Human Monocytic Cell Line THP-1: D. Kim, et al.; Int. J. Mol. Sci. 11, 3769 (2011), Abstract; Full Text
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88: U. Hasan, et al.; J. Immunol. 174, 2942 (2005), Abstract; Full Text

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