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(R,S)-ATPA

Kainate receptor agonist
 
ALX-550-352-M005 5 mg 82.00 USD
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Potent and selective agonist of the GluR5 subtype of the kainate receptor.

Product Specification

Alternative Name:(R,S)-α-Amino-3-hydroxy-5-t-butyl-4-isoxazolepropionic acid
 
Formula:C10H16N2O4
 
MW:228.2
 
CAS:140158-50-5
 
Purity:≥97%
 
Identity:Determined by NMR.
 
Appearance:White crystalline powder.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-550-352
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ALX-550-352

Product Literature References

Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord: M.J. Procter, et al.; Neuropharmacology 37, 1287 (1998), Abstract;
Pharmacological profile of the isomers of the GluR-specific agonist ATPA: K. Curry & H. Pajouhesh; Can. J. Physiol. Pharmacol. 76, 690 (1998), Abstract;
The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus: M. Vignes, et al.; Neuropharmacology 37, 1269 (1998), Abstract;
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission: V.R. Clarke, et al.; Nature 389, 599 (1997), Abstract;
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors: J. Lauridsen, et al.; J. Med. Chem. 28, 668 (1985), Abstract;

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