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IL-33 (mouse), (recombinant)

 
ALX-522-101-C010 10 µg 277.00 USD
 
ALX-522-101-3010 3x10 µg SuperPack 563.00 USD
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Product Specification

Alternative Name:Interleukin-33, NF-HEV, IL-1F11
 
MW:~18kDa
 
Source:Produced in E. coli. Untagged mouse IL-33 (aa 109-266).
 
UniProt ID:Q8BVZ5
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Associates of Cape Cod).
 
Specificity:Binds to mouse and human ST2.
 
Reconstitution:Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background:IL-33 is a member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The mouse IL-33 protein is expressed with a prodomain (aa 1-108) which is cleaved to produce the 18kDa mature protein (109-266). Historical data has shown that IL-33 activates mouse and human ST2-dependent NF-κB pathway and induces IL-6 production in P815 mastocytoma cells and in bone marrow derived mast cells.
 
ALX-522-101 SDS PAGE
SDS-PAGE analysis: Lane 1: MW Marker; Lane 2: 1.0ug of purified IL-33 (mouse), (recombinant).
ALX-522-101 WB
Western Blot analysis: Lane 1: MW Marker; Lane 2: 100ng of purified IL-33 (mouse), (recombinant) protein probed with IL-33 mAb (Prod. no. ALX-804-840PF-C100) at 0.5ug/ml.
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ALX-522-101 SDS PAGE ALX-522-101 WB

Product Literature References

IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis: C. De Salvo, et al.; Am. J. Pathol. 186, 885 (2016), Application(s): Experimental in Vivo Studies, Abstract;
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells: S. Ali, et al.; PNAS 104, 18660 (2007), Abstract;

General Literature References

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

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