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IL-33 (human), (recombinant)

ALX-522-098-C010 10 µg 256.00 USD
ALX-522-098-3010 3x10 µg SuperPack 614.00 USD
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Product Details

Alternative Name:Interleukin-33, NF-HEV, IL-1F11
Source:Produced in E. coli. Untagged human IL-33 (aa 112-270).
UniProt ID:O95760
Concentration:0.1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Associates of CAPE COD Inc.).
Specificity:Binds to human ST2.
Reconstitution:Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Scientific Background:IL-33 is a member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270). Historical data has shown that IL-33 activates human ST2-dependent NF-κB pathway, but it does not activate mouse ST2-dependent NF-κB.
Regulatory Status:RUO - Research Use Only
IL-33 (human), (recombinant) SDS-PAGE
SDS-PAGE Analysis. Lane 1: MWM; Lane 2: 1.0 µg of purified IL-33 (human), (recombinant).
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IL-33 (human), (recombinant) SDS-PAGE

Product Literature References

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye: S. Theodoropoulou, et al.; J. Pathol. 241, 45 (2017), Abstract; Full Text
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33: T. Pecaric-Petkovic et al.; Blood 113, 1526 (2009), Abstract;
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo: V. Carriere et al.; PNAS 104, 282 (2007), Abstract;

General Literature References

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

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