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Bafilomycin C1

V-ATPase inhibitor
 
ALX-380-209-M001 1 mg 556.00 USD
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Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.

Product Specification

Alternative Name:L-681,110A1
 
Formula:C39H60O12
 
MW:720.9
 
Source:Isolated from Streptomyces sp. MST-AS5338.
 
CAS:88979-61-7
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to light-brown solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions. Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:After reconstitution protect from light at -20°C.
 
380-209
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380-209

Product Literature References

Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007), Abstract;
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995), Abstract;
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993), Abstract;
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984), Abstract;

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