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Encecalin

Antifungal agent
 
ALX-350-393-M001 1 mg 134.00 USD
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Exhibits antifungal activity. Putative compound for the treatment of the dermatophytes Trichophyton rubrum and T. mentagrophytes, the causative agents of tinea pedis infection. Has also been shown to exhibit phytotoxic effects by inhibiting the photosystem I (but not photosystem II) of isolated spinach chloroplasts in a dose dependent manner. The site of inhibition has been located in the span from P680 to QA of the electron transport chain.

Product Specification

Formula:C14H16O3
 
MW:232.3
 
Source:Isolated from Encelia farinosa
 
CAS:20628-09-5
 
Purity:≥96% (HPLC)
 
Identity:Identity determined by 1H-NMR and ESI-MS.
 
Appearance:Off-white to yellowish solid.
 
Solubility:Soluble in 100% ethanol or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Scientific Background:2,2-Dimethylchromenes are characteristic natural products of many Asteraceae and other related tribes. Several of the naturally occuring chromenes have been shown to exhibit a variety of biological activities, including phototoxic properties against microorganisms, toxicity against herbivorous insects, phytotoxic effects and antifungal activity.
 
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Product Literature References

Active compounds against tinea pedis dermatophytes from Ageratina pichinchensis var. bustamenta: B. Aguilar-Guadarrama, et al.; Nat. Prod. Res. 23, 1559 (2009), Abstract;
Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox: O. Romero-Cerecero, et al.; Planta Med. 74, 1430 (2008), Abstract;
Interactions between the Encelia leaf beetle and its host plant, Encelia farinosa: The influence of acidic fog on insect growth and plant chemistry: R. A. Redak, et al.; Environ. Pollut. 95, 241 (1997), Abstract;
Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis: P. Castañeda, et al.; J. Nat. Prod. 59, 323 (1996), Abstract;
Accumulation and Biotransformation of Chromenes and Benzofurans in a Cell Suspension Culture of Ageratina adenophora: P. Proksch, et al.; Planta Med. 53, 488 (1987), Abstract;
An elegant synthesis of some naturally occurring linear acetylchromenes: eupatriochromene, methyleupatriochromene (encecalin); evodionol and methylevodionol: V. K. Ahluwalia, et al.; Tetrahedron 38, 609 (1982),

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Demethoxyencecalin 

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