Isolated from Microcystis aeruginosa. Microcystin containing arginine (R) in positions 2 and 4. Additionally, the D-MeAsp at position 3 is demethylated to Asp. Hepatotoxic.
Product Specification
Alternative Name:
Microcystin-RR (desmethylated)
Formula:
C48H73N13O12
MW:
1024.2
Source:
Isolated from Microcystis aeruginosa.
Purity:
≥95% (HPLC)
Identity:
Identity determined by MS.
Appearance:
Pale powder or film.
Solubility:
Soluble in methanol or DMSO.
Shipping:
Ambient
Long Term Storage:
-20°C
Scientific Background:
Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
Please mouse over
Product Literature References
Development of an analytical method for the unambiguous structure elucidation of cyclic peptides with special appliance for hepatotoxic desmethylated microcystins: T. Kruger, et al.; Toxicon 54, 302 (2009), Abstract;
