Isolated from Microcystis aeruginosa. Microcystin containing arginine (R) in positions 2 and 4. Additionally, the D-MeAsp at position 3 is demethylated to Asp. Hepatotoxic.
Product Specification
Alternative Name:
Microcystin-RR (desmethylated)
Formula:
C48H73N13O12
MW:
1024.2
Source:
Isolated from Microcystis aeruginosa.
Purity:
≥95% (HPLC)
Identity:
Identity determined by MS.
Appearance:
Pale powder or film.
Solubility:
Soluble in methanol or DMSO.
Shipping:
Ambient
Long Term Storage:
-20°C
Scientific Background:
Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
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Product Literature References
First observation of microcystin- and anatoxin-a-producing cyanobacteria in the easternmost part of the Gulf of Finland (the Baltic Sea): E. Chernova, et al.; Toxion 157, 18 (2018), Abstract;
Development of an analytical method for the unambiguous structure elucidation of cyclic peptides with special appliance for hepatotoxic desmethylated microcystins: T. Kruger, et al.; Toxicon 54, 302 (2009), Abstract;
