[D-Asp3]microcystin-RR



ALX-350-168-C025	25 µg	163.00 USD

ALX-350-168-C100	100 µg	357.00 USD

Isolated from Microcystis aeruginosa. Microcystin containing arginine (R) in positions 2 and 4. Additionally, the D-MeAsp at position 3 is demethylated to Asp. Hepatotoxic.

Product Specification

Alternative Name:	Microcystin-RR (desmethylated)

Identity:	Identity determined by MS.

Formula:	C₄₈H₇₃N₁₃O₁₂

MW:	1024.2

Purity:	≥95% (HPLC)

Appearance:	Pale powder or film.

Source/Host:	Isolated from Microcystis aeruginosa.

Solubility:	Soluble in methanol or DMSO.

Long Term Storage:	-20°C

Hazard:	HIGHLY IRRITANT. MAY BE CARCINOGENIC. TOXIC.

Background / Technical Information:	Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala¹-X²-D-MeAsp³-Y⁴-Adda⁵-D-Glu⁶-Mdha⁷-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-ß-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C₂₀ ß-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

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Product Literature References

Development of an analytical method for the unambiguous structure elucidation of cyclic peptides with special appliance for hepatotoxic desmethylated microcystins: T. Kruger, et al.; Toxicon 54, 302 (2009), Abstract;