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O6-Methylguanine-DNA methyltransferase polyclonal antibody

 
ALX-210-551-R100 100 µl 220.00 USD
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Product Specification

Alternative Name:MGMT
 
Host:Rabbit
 
Immunogen:Human MGMT (O6-methylguanine-DNA methyltransferase).
 
UniProt ID:P16455
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:100-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Contains 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:O6-Methylguanine-DNA methyltransferase (MGMT) removes O6-methylguanine from DNA by transferring the O6-alkyl group to a specific cysteine residue within its own sequence irreversibly inactivating MGMT. Unrepaired alkylated guanine will cause G·C -> A·T transition mutations by anomalous base pairing during DNA replication. DNA damage by O6-methylguanine can induce apoptosis regulated by Bcl-2 and caspases- 3 & -9. MGMT is able to remove O4-alkylated-thymine.
 

Product Literature References

O6-methylguanine-DNA methyltransferase activity in breast and brain tumors: I. Preuss, et al.; Int. J. Cancer 61, 321 (1995), Abstract;

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