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Bag-1 polyclonal antibody

ADI-905-735-100 100 µg 363.00 USD
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Product Specification

Alternative Name:Bcl-2 associated athanogene-1, BAG family molecular chaperone regulator 1, RAP46
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human BAG-1.
UniProt ID:Q99933
Species reactivity:Human, Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~37kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Bag-1 is a multifunctional Bcl-2-binding protein that lacks sequence homology with Bcl-2 and its related proteins, and functions to enhance the anti-apoptotic effects of Bcl-2. Bag-1 binds to the intracellular domain of the hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF) receptors, enhancing growth factor mediated protection from apoptosis. Bag-1 is known to modulate the chaperone activity of Hsc70/Hsp70, serving as a nucleotide exchange factor via binding to the ATPase domain of Hsc70/Hsp70. Bag-1 is known to promote cell survival through activation of the Raf-1 kinase.
905-735 WB
Western blot analysis of PC-3 cell lysate at (A) 1 and (B) 2µg/ml, probed with BAG-1, pAb.
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905-735 WB

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