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TIMP-1 polyclonal antibody

 
ADI-905-584-1 1 ml 366.00 USD
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Product Specification

Alternative Name:Tissue inhibitor of matrix metalloproteinases 1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human TIMP-1.
 
UniProt ID:P01033
 
Gene/Protein Identifier:7076 (Entrez GeneID)
 
Species reactivity:Human
 
Applications:IHC
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~28kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.6, containing 1% BSA and 0.1% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) share similar properties, specifically in inhibiting enzymes of the matrix metalloproteinase family, and both appear to play important roles in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, the active form of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms of 92kDa Type IV collagenase (also known as MMP-0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
 
905-584 IHC
Immunohistochemistry analysis of human colon cancer cells stained with TIMP-1, pAb.
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905-584 IHC

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