Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

IL-27 Inhibits HIV-1 Replication in Dendritic Cells

IL-27 is a heterodimer belonging to the IL-12 family of cytokines (which also includes IL-12, IL-23, and IL-35), and is normally produced by activated macrophages and dendritic cells (DCs) (Imamichi et al., 2008; Frank et al., 2010). Most widely known for its anti-inflammatory properties, IL-27 also shows broad anti-viral effects. Studies in recent years have indicated IL-27 may hold promise as a means of protecting macrophages and CD4+ T-cells during HIV infection by inhibiting replication of the virus. In their recent publication in PLoS One, Dr. Tomozumi Imamichi from the Laboratory of Human Retrovirology at the Frederick National Laboratory for Cancer Research (Maryland, USA) and his team demonstrated IL-27 can similarly inhibit HIV replication in both immature and mature DCs. The team confirmed expression of IL-27 receptors (IL-27R) and HIV-1 receptors on monocyte-derived DCs, and then demonstrated IL-27 was able to inhibit HIV-1 replication in a dose-dependent manner. IL-12, IL-23, and IL-35 were not capable of reproducing this protective effect. Looking further into this mechanism, expression of type I interferons were shown to be unaltered and inhibition was deemed to be type I interferon-independent, interfering with replication at a point between viral entry and completion of reverse transcription. These encouraging results suggest that IL-27-based therapies could have broad application in targeting and treating all major cell types affected by HIV-1 in the future.

Enzo Life Sciences offers immunologists a comprehensive range of products including antibodies, modulators of the type I interferon pathway, ELISA kits, and recombinant cytokines, some of which are described below:



  • Chen Q, et al. Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS One (2013) 8: e59194.
  • T. Imamichi, et al. IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages. AIDS (2008) 22 : 39-45.
  • A.C. Frank, et al. Interleukin-27, an anti-HIV-1 cytokine, inhibits replication of Hepatitis C virus. J. Interferon Cytokine Res. (2010) 30: 427-431.

Related Products

CCR5 (human) polyclonal antibody 

ELISA, ICC, IHC (PS), WB | Print as PDF
ALX-210-823-C200 200 µg 378.00 USD
Do you need bulk/larger quantities?

CD4 (human) monoclonal antibody (MEM-115) 

Flow Cytometry, IP, FUNC | Print as PDF
ALX-805-053-C100 100 µg 249.00 USD
Do you need bulk/larger quantities?

[pSer727]Stat1 monoclonal antibody (12C5) 

ELISA, WB | Print as PDF
ADI-905-670-100 100 µg 389.00 USD
Do you need bulk/larger quantities?

[pSer727]Stat3 monoclonal antibody (23G5) 

ELISA, IHC, WB | Print as PDF
ADI-905-672-100 100 µg 488.00 USD
Do you need bulk/larger quantities?

[pTyr695/Tyr699]Stat5 A/B monoclonal antibody (5G4) 

ELISA, ICC, IHC, WB | Print as PDF
ADI-905-673-100 100 µg 378.00 USD
Do you need bulk/larger quantities?

Stat1 α polyclonal antibody 

ICC, IP, WB | Print as PDF
ADI-KAP-TF001-E 100 µg 347.00 USD
Do you need bulk/larger quantities?

Stat3 monoclonal antibody (7G8) 

Purified from mouse ascites., WB | Print as PDF
ADI-905-756-100 100 µg 350.00 USD
Do you need bulk/larger quantities?

Oligo(deoxyadenosine:deoxythymidine) (endotoxin-free) (synthetic) 

IFN activator
Synthetic. | Print as PDF
ALX-746-023-C050 50 µg 211.00 USD
Do you need bulk/larger quantities?

IL-35 (human):Fc (human), (recombinant) 

Highly pure interleukin involved in T cell regulation.
Produced in HEK 293 cells. Human EBI3 (aa 21-229) linked to human IL-12A (aa 23-219) via the linker GGGSGGGSGGGSGGGS is fused at the C-terminus to the Fc portion of human IgG1 and a FLAG®-tag., ≥95% (SDS-PAGE) | Print as PDF
ALX-522-140-C010 10 µg 470.00 USD
Do you need bulk/larger quantities?

Recommend this page

Keep in touch

©2022 Enzo Life Sciences, Inc.,