Product Details
Alternative Name: | BCL2L4, BCL2-associated X protein |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to a portion of human Bax. |
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UniProt ID: | Q07812 |
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GenBank ID: | L22473 |
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Source: | Purified from rabbit serum. |
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Species reactivity: | Human, Mouse, Rat Bovine, Monkey, Porcine, Rabbit
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Applications: | WB
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Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~22kDa by Western blot. |
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Purity Detail: | Protein A affinity purified. |
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Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterized by the presence of at least one Bcl-2 homology (BH) domains. Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes where it inserts and mediates the release of cytochrome c. This activates caspase-3 and perpetuates the apoptotic cascade. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3: O. Ham, et al.; Stem Cell Res. Ther.
6, 147 (2015),
Application(s): Western blot,
Abstract;
Full Text
Retinoprotective Effects of Bilberry Anthocyanins via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms in a Visible Light-Induced Retinal Degeneration Model in Pigmented Rabbits: Y. Wang, et al. ; Molecules
20, 22395 (2015),
Application(s): Western blot,
Abstract;
Full Text
Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury: Y. Xiao, et al.; Plast. Aesthet. Res.
2, 332 (2015),
Application(s): Western blot,
Full Text
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