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United States 

Axin-1 (human), (recombinant)

 
ENZ-PRT130-0020 20 µg 416.00 USD
 
ENZ-PRT130-0050 50 µg 657.00 USD
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Product Details

Alternative Name:Axis inhibition protein 1
 
MW:~135 kDa
 
Source:Produced in Sf9 insect cells. Produced in a baculovirus expression system.
 
UniProt ID:O15169
 
Concentration:0.05 µg/µl
 
Formulation:Liquid. In 50mM TRIS-HCl, pH 7.5, containing 50mM NaCl, 10mM gluthathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
 
Purity:≥75%
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-80°C
 
Long Term Storage:-80°C
 
Scientific Background:Axin-1 has a positive and negative regulatory role in Wnt-β-catenin signaling. Axin-1 is part of the 'destruction complex' that promotes phosphorylation and polyubiquitination of cytoplasmic β-catenin.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction: K.R. Simonetta, et al.; Nat. Commun. 10, 1402 (2019), Abstract; Full Text

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