Product Details
| Alternative Name: | Axis inhibition protein 1 |
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| MW: | ~135 kDa |
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| Source: | Produced in Sf9 insect cells. Produced in a baculovirus expression system. |
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| UniProt ID: | O15169 |
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| Concentration: | 0.05 µg/µl |
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| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 50mM NaCl, 10mM gluthathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
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| Purity: | ≥75% |
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| Shipping: | Shipped on Dry Ice |
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| Short Term Storage: | -80°C |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Axin-1 has a positive and negative regulatory role in Wnt-β-catenin signaling. Axin-1 is part of the 'destruction complex' that promotes phosphorylation and polyubiquitination of cytoplasmic β-catenin. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction: K.R. Simonetta, et al.; Nat. Commun.
10, 1402 (2019),
Abstract;
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