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Ponatinib

Potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src
 
ENZ-CHM179-0005 5 mg 76.00 USD
 
ENZ-CHM179-0010 10 mg 110.00 USD
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Ponatinib is a potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 values of 0.37, 1.1, 1.5, 2.2 and 5.4 nM respectively.

Product Specification

Alternative Name:AP 24534, 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
 
Formula:C29H27F3N6O
 
MW:532.6
 
CAS:943319-70-8
 
Purity:≥98% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (107mg/ml) or ethanol (107mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
ENZ-CHM179 structure
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ENZ-CHM179 structure

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