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United States 


Aurora kinases A/B and VEGFR2 inhibitor and antitumor agent
ENZ-CHM171-0001 1 mg 68.00 USD
ENZ-CHM171-0010 10 mg 98.00 USD
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CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.

Product Details

Alternative Name:4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
Purity:≥95% (HPLC)
Identity:Determined by EM-MS, NMR
Appearance:Brown powder.
Solubility:Soluble in DMSO (24mg/ml) or ethanol (1mg/ml).
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:Aurora kinases are known to play a role in mitotic entry, progression and exit. These kinases represent attractive targets for anticancer drug development because they regulate both genomic integrity and cell cycle progression in cancer.
Regulatory Status:RUO - Research Use Only
ENZ-CHM171 structure
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ENZ-CHM171 structure