Product Details
| MW: | 47 kDa |
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| Source: | Produced in insect cells. Full length human SPHK1 is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system. |
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| UniProt ID: | Q9NYA1 |
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| Application Notes: | Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Sphingosine Kinase 1 is responsible for the conversion of sphingosine to sphingosine-1-phosphate, an important mediator of cellular processes, such as cell growth, survival, and calcium mobilization. SPHK1 is capable of using both ATP and GTP as phosphate donors. It is most highly expressed in lung and spleen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis: C. Bougault, et al.; Bone
103, 150 (2017),
Abstract;
