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Cathepsin B (human liver), (purified)

Highly pure lysosomal protease
BML-SE198-0025 25 µg 242.00 USD
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Product Specification

MW:~27.5 kDa
Source:Purified from human liver.
UniProt ID:P07858
Formulation:Liquid. In 50mM sodium acetate, pH 5.0, containing 1mM EDTA.
Purity:≥95% (SDS-PAGE)
Application Notes:Useful for inhibitor screening, kinetic studies and cleavage of substrates in vitro or in tissue culture.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:Cathepsin B is a lysosomal protease (endopeptidase and dipeptidyl carboxypeptidase) that can also be secreted from the cell and is involved in protein degradation, apoptosis, arthritis, cancer, and Alzheimer’s disease.

Product Literature References

Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation: T.J. Perlenfein, et al.; J. Biol. Chem. 292, 21071 (2017), Abstract; Full Text
Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy: J.J. Bartlett, et al.; Biochem. J. 473, 3769 (2016), Abstract;
Expression, purification, and characterization of human cystatin C monomers and oligomers: T.J. Perlenfein, et al.; Protein Expr. Purif. 117, 35 (2016), Abstract; Full Text
Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes: P.C. Trivedi, et al.; Biochim. Biophys. Acta 1861, 1893 (2016), Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem. 21, 2975 (2013), Application(s): Assay, Abstract;
Mechanisms of Dendritic Cell Lysosomal Killing of Cryptococcus: C.R. Hole, et al.; Sci. Rep. 2, 739 (2012), Application(s): Cell Culture, Abstract; Full Text

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