Product Specification
Alternative Name: | VCP, Transitional endoplasmic reticulum ATPase, TER ATPase |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to aa 20-37 of the human VCP sequence. |
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UniProt ID: | P55072 |
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Species reactivity: | Human, Mouse, Rat Porcine
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Applications: | WB
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Blocking Peptide: | For Blocking peptide see Prod. No. BML-PP9350.
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Formulation: | Liquid. Antiserum containing 10mM sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Valosin containing protein (VCP) is an abundant and a highly conserved member of the family of ATPases. Besides acting as a chaperone in membrane fusions, VCP is now recognized as a multi-ubiquitin chain-targeting factor that is required in the degradation of many ubiquitin-proteasome pathway substrates. p97/VCP is likely important in regulating both UPS- and autophagy-mediated protein degradation. This places p97/VCP in a key regulatory position at the intersection of these two proteolytic pathways. |
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Regulatory Status: | RUO - Research Use Only |
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General Literature References
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease: J.S. Ju, et al.; J.Cell.Biol.
187, 875 (2009),
Abstract;