Product Specification
| Alternative Name: | VCP, Transitional endoplasmic reticulum ATPase, TER ATPase |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 20-37 of the human VCP sequence. |
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| UniProt ID: | P55072 |
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| Species reactivity: | Human, Mouse, Rat
Porcine
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| Applications: | WB
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| Blocking Peptide: | For Blocking peptide see Prod. No. BML-PP9350.
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| Formulation: | Liquid. Antiserum containing 10mM sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Valosin containing protein (VCP) is an abundant and a highly conserved member of the family of ATPases. Besides acting as a chaperone in membrane fusions, VCP is now recognized as a multi-ubiquitin chain-targeting factor that is required in the degradation of many ubiquitin-proteasome pathway substrates. p97/VCP is likely important in regulating both UPS- and autophagy-mediated protein degradation. This places p97/VCP in a key regulatory position at the intersection of these two proteolytic pathways. |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease: J.S. Ju, et al.; J.Cell.Biol.
187, 875 (2009),
Abstract;
