Replaces Prod. #: ALX-630-102
A potent, cell-permeable histone deacetylase (HDAC) inhibitor. Inhibits HDACs in maize, Physarum and chicken. IC50=30nM for E. tenella HDAC. Displays antiprotozoal and antineoplastic activity. Induces expression of the γ-globin gene in erythroid cells. Shows antimitogenic activities. Induces cell cycle arrest and apoptosis in tumor cells.
Product Details
| Alternative Name: | Cyclo-(D-Pro-L-Ala-D-Ala-L-2-amino-8-oxo-9,10-epoxydecanoic acid) |
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| Formula: | C21H32N4O6 |
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| MW: | 436.5 |
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| CAS: | 83209-65-8 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Technical Info/Product Notes: | Toxic against maize. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem.
286, 22211 (2011),
Abstract;
Full Text
HC-toxin: J.D. Walton; Phytochemistry
67, 1406 (2006),
Abstract;
Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells: K.E. Joung et al.; Arch. Pharm. Res.
27, 640 (2004),
Abstract;
Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells: K.N. Min et al.; Arch. Pharm. Res.
27, 554 (2004),
Abstract;
Induction of gamma-globin by histone deacetylase inhibitors: P.G. McCaffrey, et al.; Blood
90, 2075 (1997),
Abstract;
Full Text
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase: S.J. Darkin-Rattray, et al.; PNAS
93, 13143 (1996),
Abstract;
Full Text
Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum: G. Brosch, et al.; Plant Cell
7, 1941 (1995),
Abstract;
Isolation and Biological Activities of Four Selective Toxins from Helminthosporium carbonum: J.B. Rasmussen & R.P. Scheffer; Plant Physiol.
86, 187 (1988),
Abstract;
The structure and conformation of HC-toxin: M. Kawai, et al.; Biochem. Biophys. Res. Commun.
111, 398 (1983),
Abstract;
