Replaces Prod. #: ALX-350-086
Antioxidant and antineoplastic. Lipoxygenase inhibitor (IC50=0.2, 30 and 30µM for 5-, 12- and 15-LO respectively) over cyclooxygenase (IC50=100µM). Inhibits rat epidermal and hepatic microsomal cytochrome P-450 (ID50=40µM).. Stimulates the rapid retrograde movement of both Golgi stacks and the trans-Golgi network to the endoplasmatic reticulum (ER). Displays pleiotropic effects on cells, which include apoptosis, cell proliferation, differentiation and chemotaxis. Anticancer agent.
Product Details
| Alternative Name: | NDGA, 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol] |
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| Formula: | C18H22O4 |
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| MW: | 302.4 |
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| Source: | Synthetic. |
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| CAS: | 500-38-9 |
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| MI: | 14: 6693 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, methanol or acetone; slightly soluble in hot water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells: K. Arasaki, et al.; Mol. Pharmacol.
71, 454 (2007),
Abstract;
Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro: Y.H. Siddique, et al.; J. Environ. Biol.
28, 279 (2007),
Abstract;
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs: E. Floriano-Sanchez, et al.; Free Radic. Res.
40, 523 (2006),
Abstract;
The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling: C.A. Culver, et al.; Life Sci.
77, 2457 (2005),
Abstract;
Stepwise dissection of the intracellular fate of cationic cell-penetrating peptides: R. Fischer, et al.; J. Biol. Chem.
279, 12625 (2004),
Abstract;
Full Text
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid: T. Fujiwara, et al.; BBRC
301, 927 (2003),
Abstract;
Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase: S.M. Kim, et al.; J. Biochem. Mol. Biol.
35, 518 (2002),
Abstract;
Full Text
Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid: H. Yamamura, et al.; Jpn. J. Pharmacol.
89, 53 (2002),
Abstract;
Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem.
273, 3068 (1998),
Abstract;
Full Text
Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid: M. Pavani, et al.; Biochem. Pharmacol.
48, 1935 (1994),
Abstract;
Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes: R. Agarwal, et al.; Drug Metab. Dispos.
19, 620 (1991),
Abstract;
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med.
13, 53 (1984),
Abstract;
In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin:: W.C. Hope, et al.; Biochem. Pharmacol.
32, 367 (1983),
Abstract;
