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Cytochrome P450 2D1 (rat) polyclonal antibody

BML-CR3210-0025 25 µl 108.00 USD
BML-CR3210-0100 100 µl 381.00 USD
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Product Details

Alternative Name:CYP2D1
Immunogen:Synthetic peptide corresponding to a portion of C-terminal rat liver CYP2D1.
UniProt ID:P10633
Species reactivity:Human, Rat
Applications:IHC, WB
Blocking Peptide:For Blocking peptide see Prod. No. BML-CP0201.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Rat cytochrome P-450 2D1 (CYP2D1), the homologue of human CYP2D6, has been shown to catalyse the conversion of hydrocodone to hydromorphone, and in rat liver microsomes it participates in the conversion of ethylmorphine to codine and morphine. Its regional distribution in the rat brain has been described. Mutation in the cyp2D6 gene has been reported to be associated with Parkinson's Disease.
Regulatory Status:RUO - Research Use Only
Cytochrome P450 2D1 (rat) polyclonal antibody Western blot
Figure 1. Liver microsomal fraction was prepared from rats which were either untreated (UT) or treated with 3 methylcholanthrene (MC), sodium phenobarbitone (PB), streptozotocin (STZ), or pregnenolone 16α-carbonitrile (PCN). To each lane 10 μg of microsomal protein was applied. After electro-transfer onto nitrocellulose filters, each blot was developed with antiserum diluted 1:4,000. Only the central section of blots corresponding to the molecular weight range of 50-60 kDa are shown. No other immunoreactive bands were detected.
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Cytochrome P450 2D1 (rat) polyclonal antibody Western blot

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