Replaces Prod. #: ALX-380-050
Acts as an H+, K+, Na+, Pb2+ ionophore. Is most commonly an antiporter of H+ and K+. Stimulates Ca2+ release from mitochondrial stores by disruption of membrane potantial. Inhibits the Golgi functions. Activator of NALP3.
Product Details
| Alternative Name: | Antibiotic K 178 |
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| Formula: | C40H67O11 . Na |
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| MW: | 746.9 |
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| CAS: | 28643-80-3; 28380-24-7 |
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| MI: | 14: 6541 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (10mg/ml, heating may be required), dichloromethane (10mg/ml), methanol (10mg/ml), ethanol (5mg/ml) and ethyl acetate. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption: M.A. Gianfrancesco, et al.; Biochim. Biophys. Acta Mol. Cell Bio. Lipids
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Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin: A. Taracanova, et al.; PNAS
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Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration: S.H. Fan, et al. ; Mol. Biol. Cell.
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Application(s): Cell culture,
Abstract;
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Cryopyrin activates the inflammasome in response to toxins and ATP: S. Mariathasan, et al.; Nature
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The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry
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Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: C.Y. Chu, et al.; J. Cell. Biochem.
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Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis: S.R. King, et al.; Mol. Cell. Endocrinol.
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Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release: R. Rodriguez & M. Sitges; Neurochem. Res.
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Abstract;
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria: A.E. Vercesi, et al.; J. Biol. Chem.
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Abstract;
ntracellular processing and transport of influenza-virus envelope proteins in Madin-Darby canine kidney cells. Effects of the carboxylic ionophores monensin and nigericin: P.U. Daniels & J.M. Edwardson; Biochem. J.
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Nigericin, a new crystalline antibiotic from an unidentified streptomyces: R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951),
