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Nigericin . sodium salt

NALP3 activator
BML-CA421-0005 5 mg 77.00 USD
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Replaces Prod. #: ALX-380-050

Acts as an H+, K+, Na+, Pb2+ ionophore. Is most commonly an antiporter of H+ and K+. Stimulates Ca2+ release from mitochondrial stores by disruption of membrane potantial. Inhibits the Golgi functions. Activator of NALP3.

Product Details

Alternative Name:Antibiotic K 178
Formula:C40H67O11 . Na
CAS:28643-80-3; 28380-24-7
MI:14: 6541
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (10mg/ml, heating may be required), dichloromethane (10mg/ml), methanol (10mg/ml), ethanol (5mg/ml) and ethyl acetate.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
BML-CA421 structure
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BML-CA421 structure

Product Literature References

Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin: A. Taracanova, et al.; PNAS 115, E9381 (2018), Abstract;
Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration: S.H. Fan, et al. ; Mol. Biol. Cell. 27, 702 (2016), Application(s): Cell culture, Abstract; Full Text
Cryopyrin activates the inflammasome in response to toxins and ATP: S. Mariathasan, et al.; Nature 440, 228 (2006), Abstract;
The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43, 15956 (2004), Abstract;
Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: C.Y. Chu, et al.; J. Cell. Biochem. 85, 83 (2002), Abstract;
Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis: S.R. King, et al.; Mol. Cell. Endocrinol. 166, 147 (2000), Abstract;
Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release: R. Rodriguez & M. Sitges; Neurochem. Res. 21, 889 (1996), Abstract;
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria: A.E. Vercesi, et al.; J. Biol. Chem. 268, 8564 (1993), Abstract;
ntracellular processing and transport of influenza-virus envelope proteins in Madin-Darby canine kidney cells. Effects of the carboxylic ionophores monensin and nigericin: P.U. Daniels & J.M. Edwardson; Biochem. J. 252, 693 (1988), Abstract;
Nigericin, a new crystalline antibiotic from an unidentified streptomyces: R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951),

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