Product Details
| Alternative Name: | Multidrug resistance-associated protein MGr1-Ag, 37-kDa laminin receptor precursor, 37LRP, p40 ribosome-associated protein |
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| Clone: | MPLR2 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human 37kDa-laminin receptor precursor (37LRP). |
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| UniProt ID: | P08865 |
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| Species reactivity: | Human
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| Specificity: | Recognizes human 37kDa laminin receptor precursor. Depending on solubilization, can also recognize the 67kDa mature form of the laminin receptor (67LR). |
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| Applications: | WB
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| Application Notes: | Detects a band of ~37kDa by Western blot. |
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| Formulation: | Liquid. Purified antibody containing 150mM sodium chloride and 0.02% sodium azide, pH 7.4. |
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| Handling: | Do not freeze. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Scientific Background: | The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. They are mediated by different cell surface molecules such as the 67kD laminin receptor (67LR; laminin receptor 1), a protein derived from a smaller precursor, the 37LRP. In addition to its role as laminin receptor, 67LR also acts as a receptor for viruses and is involved with internalization of the prion protein. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Human recombinant laminin-binding protein: isolation, purification, and crystallization: A.V. Sorokin, et al.; Biochemistry (Mosc).
65, 546 (2000),
Abstract;
Laminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrins: M. Vivinus-Nebot, et al.; J. Cell Biol.
144, 563 (1999),
Abstract;
Formation of the 67-kDa laminin receptor by acylation of the precursor: S. Buto, et al.; J. Cell. Biochem.
69, 244 (1998),
Abstract;
Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin: E. Ardini, et al.; J. Biol. Chem.
272, 2342 (1997),
Abstract;
Production and characterization of monoclonal antibodies directed against the laminin receptor precursor: S. Buto, et al.; Int. J. Biol. Markers
12, 1 (1997),
Abstract;
General Literature References
The 67 kDa laminin receptor: structure, function and role in disease: J. Nelson, et al.; Biosci. Rep.
28, 33 (2008),
Abstract;
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