Recombinant human BCMA extracellular domain (aa 2-54) (Prod. No. ALX-522-026).
UniProt ID:
Q02223
Source:
Purified from ascites.
Species reactivity:
Human
Crossreactivity:
Does not cross-react with mouse BCMA.
Applications:
ELISA, WB
Recommended Dilutions/Conditions:
ELISA (1:1,000) Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Purity Detail:
Protein G-affinity purified.
Formulation:
Liquid. In PBS containing 0.02% sodium azide.
Handling:
Avoid freeze/thaw cycles.
Shipping:
Shipped on Blue Ice
Short Term Storage:
+4°C
Long Term Storage:
-20°C
Scientific Background:
BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.
Regulatory Status:
RUO - Research Use Only
Western Blot Analysis of BCMA: Lane 1: MWM, Lane 2: BCMA (human):Fc (human), (recombinant) (Prod. No. ALX-522-026)
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General Literature References
TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase: A. Hatzoglou, et al.; J. Immunol. 165, 1322 (2000), Abstract;
Produced in HEK 293 cells. The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1., ≥95% (SDS-PAGE), ELISA, Flow Cytometry | Print as PDF