Product Specification
| Alternative Name: | Major vault protein/Lung resistance protein |
| |
| Clone: | LMR5 |
| |
| Host: | Rat |
| |
| Isotype: | IgG2a |
| |
| Immunogen: | Human MVP/LRP (major vault protein/lung resistance protein). |
| |
| UniProt ID: | Q14764 |
| |
| Species reactivity: | Human
|
| |
| Specificity: | Recognizes an internal epitope of human MVP/LRP, which is strongly overexpressed in various human non-P-glycoprotein MDR tumor cell lines. |
| |
| Applications: | Flow Cytometry, ICC, IHC (FS), IHC (PS)
|
| |
| Recommended Dilutions/Conditions: | Recommended starting dilution is 1:20
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
| |
| Application Notes: | Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations |
| |
| Formulation: | Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
| |
| Shipping: | Shipped on Blue Ice |
| |
| Short Term Storage: | +4°C |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies: A.B. Schroeijers, et al.; J. Histochem. Cytochem.
49, 1379 (2001),
Abstract;
Clinical relevance of the lung resistance protein in diffuse large B-cell lymphomas: M. Filipits, et al.; Clin. Cancer Res.
6, 3417 (2000),
Abstract;
Full Text
Expression of lung resistance protein in epithelioid sarcoma in vitro and in vivo: H. Kusakabe, et al.; Arch. Dermatol. Res.
292, 292 (2000),
Abstract;
Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas: D. Mayr, et al.; Pathol. Res. Pract.
196, 469 (2000),
Abstract;
MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells: G.K. Chen, et al.; Br. J. Cancer
83, 892 (2000),
Abstract;
Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines: V. Nuessler, et al.; Leukemia
13, 1864 (1999),
Abstract;
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma: H.J. Arts, et al.; Clin. Cancer Res.
5, 2798 (1999),
Abstract;
Full Text
Expression of the lung resistance protein (LRP) in primary breast cancer: G. Pohl, et al.; Anticancer Res.
19, 5051 (1999),
Abstract;
Expression of the lung resistance protein predicts poor outcome in patients with multiple myeloma: M. Filipits, et al.; Clin. Cancer Res.
5, 2426 (1999),
Abstract;
Full Text
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol.
52, 450 (1999),
Abstract;
Multidrug resistance related proteins in primary cutaneous lymphomas: C.W. van Haselen, et al.; Adv. Exp. Med. Biol.
457, 119 (1999),
Abstract;
Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts: M. Pallis, et al.; Adv. Exp. Med. Biol.
457, 77 (1999),
Abstract;
The lung resistance protein (LRP) predicts poor outcome in acute myeloid leukemia: R. Pirker, et al.; Adv. Exp. Med. Biol.
457, 133 (1999),
Abstract;
Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues: A.B. Schroeijers, et al.; Am. J. Pathol.
152, 373 (1998),
Abstract;
Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma: H.G. Raaijmakers, et al.; Blood
91, 1029 (1998),
Abstract;
Full Text
Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival: A.G. Borg, et al.; Br. J. Haematol.
103, 1083 (1998),
Abstract;
Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia: M.L. Den Boer, et al.; Blood
91, 2092 (1998),
Abstract;
Full Text
Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies: M.J. Flens, et al.; Int. J. Cancer
73, 249 (1997),
Abstract;
Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia
11, 1078 (1997),
Abstract;
Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP: U. Stein, et al.; J. Natl. Cancer Inst.
89, 807 (1997),
Abstract;
Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors: M.A. Izquierdo, et al.; Am. J. Pathol.
148, 877 (1996),
Abstract;
Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia: A.F. List, et al.; Blood
87, 2464 (1996),
Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am J. Pathol.
147, 1545 (1995),
Abstract;
The drug resistance-related protein LRP is the human major vault protein: G.L. Scheffer, et al.; Nature Med.
1, 578 (1995),
Abstract;
The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification: M.L. Slovak, et al.; Cancer Res.
55, 4214 (1995),
Abstract;
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance: R.J. Scheper, et al.; Cancer Res.
53, 1475 (1993),
Abstract;
