Selective group II mGluR antagonist.
Product Details
| Alternative Name: | MCCG, α-Methyl-L-CCG I |
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| Formula: | C7H11NO4 |
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| MW: | 173.2 |
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| CAS: | 157141-16-7 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble to 50mM in 1 eq. of NaOH or dilute aqueous base. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Attenuation of morphine withdrawal symptoms by subtype-selective metabotropic glutamate receptor antagonists: M.E. Fundytus, et al.; Br. J. Pharmacol.
120, 1015 (1997),
Abstract;
Metabotropic glutamate receptor antagonists, like GABA(B) antagonists, potentiate dorsal root-evoked excitatory synaptic transmission at neonatal rat spinal motoneurons in vitro: C.Q. Cao, et al.; Neuroscience
78, 243 (1997),
Abstract;
Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices: M.C. Kemp, et al.; Eur. J. Pharmacol.
309, 79 (1996),
Abstract;
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol.
117, 1493 (1996),
Abstract;
Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamu: T.E. Salt & S.A. Eaton; Neuroscience
65, 5 (1995),
Abstract;
Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes: T. Knöpfel, et al.; Neuropharmacology
34, 1099 (1995),
Abstract;
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord: D.E. Jane, et al.; Br. J. Pharmacol.
112, 809 (1994),
Abstract;
