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CD70 (soluble) (mouse), (recombinant)

ALX-522-030-C010 10 µg 469.00 USD
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Product Details

Alternative Name:CD27L, TNFSF 7
MW:~28kDa (SDS-PAGE).
Source:Produced in HEK 293 cells. The extracellular domain of mouse CD70 (CD27L) (aa 52-195) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag.
UniProt ID:O55237
Gene/Protein Identifier:A000547 (UCSD Signaling Gateway ID)
Concentration:0.1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity:≥95% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Species reactivity:Human, Mouse
Specificity:Binds to human and mouse CD27.
Application Notes:ELISA: binds to CD27 receptor.
Can be used together with anti-FLAG® MAb to detect membrane-bound human and mouse CD27. rmsCD70 saturates its receptor at a concentration range of 0.06-60ng/ml.
Reconstitution:Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Scientific Background:The CD27 ligand (CD27L, CD70) is a member of the tumor necrosis factor (TNF) family. CD27L is a type II, transmembrane protein. Engagement of CD27 by CD27L induces recruitment of TNF receptor-associated factor 2 (TRAF2) and TRAF3. CD27-CD70 interactions have been reported to be involved in several different immune mechanisms such as T, NK and B lymphocytes interactions and costimulation, early thymic differentiation, autoimmune and viral diseases and apoptosis. CD70 is a marker for mature B cells.
Regulatory Status:RUO - Research Use Only

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