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HVEM (human):Fc (human), (recombinant)

ALX-522-017-C050 50 µg 548.00 USD
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Product Specification

Alternative Name:TR2, ATAR, LIGHT-R, TNFRSF 14, Herpes virus entry mediator A
MW:~58kDa (SDS-PAGE).
Source:Produced in HEK 293 cells. The extracellular domain of human HVEM (aa 39-200) is fused to the Fc portion of human IgG1.
UniProt ID:Q92956
Concentration:1mg/ml, after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity:≥95% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Species reactivity:Human, Mouse
Specificity:Binds human and mouse LIGHT. 
Application Notes:ELISA: binds to LIGHT).
Detection of membrane-bound human and mouse LIGHT (HVEML) in combination with PAb to human IgG1.
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Scientific Background:HVEM (TR2, ATAR, HVEA) is a 36 kDa type I transmembrane protein belonging to the TNF receptor family. HVEM contains 3 cysteine-rich repeats in the extracellular portion which is typical of TNFR family members. HVEM mediates Herpes Simplex Virus-1 infection of T cells. Ligation of HVEM by its cellular trimeric ligand LIGHT (Prod. No. ALX-522-018) induces recruitment to the cytoplasmic domain of the signaling molecules TRAF2 and 5. Activation in vitro of HVEM leads to induction of nuclear factors NFκB and AP-1. The outcome of HVEM activation on T cells is still controversial. A second ligand for HVEM is soluble LTalpha. Historical data has shown the inhibition of LIGHT-mediated effects, such as the cytotoxic effect on HT29 target cells. Prevents Herpes Simplex Virus-1 infection of T-cells.
Regulatory Status:RUO - Research Use Only

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