cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.
Product Details
| Alternative Name: | 8-Cl-cAMP . Na |
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| Formula: | C10H10ClN5O6P . Na |
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| MW: | 362.6 . 23.0 |
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| CAS: | 41941-56-4 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Identity determined by 31P- NMR, 1H-NMR, ESI-MS and UV. |
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| Appearance: | White to off-white powder. |
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| Solubility: | At least 200mM soluble in water, aqueous buffers, methanol, DMSO and dimethylformamide; sparingly soluble in 100% ethanol (13mM). May produce hazy solutions. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Micromolar quantities can be determined by UV at λmax = 262nm, ε = 17,000 (pH 7). |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity: D. Poppe, et al.; Stem Cells Transl. Med.
7, 477 (2018),
Abstract;
Full Text
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth: S. Ally, et al.; PNAS
85, 6319 (1988),
Abstract;
