Metabolically resistant activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). No metabolic side effects as observed with dibutyryl-cAMP (N6,O2'-Dibutyryladenosine 3',5'-cyclic monophosphate, Prod. No. BML-CN125) or 8-Br-cAMP (8-Bromoadenosine-3',5'-cyclic monophosphate, Prod. No. BML-CN115). Significantly more lipophilic and membrane permeant as compared to Sp-cAMPS (Adenosine 3',5'-cyclic monophosphothioate, Sp isomer, Prod. No. BML-CN136).
Product Details
| Alternative Name: | Sp-8-Br-cAMPS . Na, 8-Br-cAMPS . Na, Sp-isomer |
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| Formula: | C10H10BrN5O5PS . Na |
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| MW: | 423.2 . 23.0 |
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| CAS: | 127634-20-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water or aqueous buffer. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium: P. Schaap, et al.; J. Biol. Chem.
268, 6323 (1993),
Abstract;
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