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Dibutyryl-cAMP

PKA activator
 
BML-CN125-0030 30 mg 81.00 USD
 
BML-CN125-0100 100 mg 161.00 USD
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Replaces Prod. #: ALX-480-045

  • Cell-permeable PKA activator
  • Compound used to study neurogenesis
Dibutyryl-cAMP (DB-cAMP) is a cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (e.g. protein kinase A) and inhibits phosphodiesterases. Used together with other compounds, DB-cAMP increases survival rate and promote differentiation of neural stem/progenitor cells into neurons in vivo. DB-cAMP also has anti-inflammatory properties and can be used to facilitate wound healing. Caution: Due to extra- and intra-cellular esterases, DB-cAMP releases butyrate, which may have distinct biological effects.

Product Details

Alternative Name:Dibutyl cyclic AMP sodium salt, N6-2'-O-dibutyryladenosine-3',5'-cyclic monophosphate, DB-cAMP
 
Formula:C18H23N5O8P . Na
 
MW:491.4
 
Source:Synthetic.
 
CAS:16980-89-5
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by MS, 1H-NMR, 31P-NMR, and UV spectrum.
 
Appearance:White crystalline solid.
 
Solubility:Soluble in DMSO (200mM), 96% ethanol (25mM), or water (100mg/ml).
 
Shipping:Ambient Temperature
 
Long Term Storage:-20°C
 
Use/Stability:Solution must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification: A. Vuidel, et al.; Stem Cell Reports 17, 2349 (2022), Abstract;
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin: J. Ha, et al.; Sci. Adv. 8, eabk1239 (2022), Abstract;
Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons: L.F. Ornelas, et al.; NPJ Parkinsons Dis. 8, 118 (2022), Abstract;
Quantification of Neurite Degeneration with Enhanced Accuracy and Efficiency in an In Vitro Model of Parkinson’s Disease: R.T. Clements, et al.; eNeuro 9, ENEURO.0327-21.2022 (2022), Abstract;
Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons: A.M. Earley, et al.; Sci. Rep. 11, 22257 (2021), Abstract;
Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease: J. Ha, et al.; Front Cell Dev Biol 8, 594090 (2020), Abstract;
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons: C. Uberbacher, et al.; Stem Cell Res. 41, 101656 (2019), Abstract;
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation: C. Sheng, et al.; Nat Commun. 9, 4047 (2018), Abstract; Full Text
Bacterial endosymbionts influence host sexuality and reveal reproductive genes of early divergent fungi: S.J. Mondo, et al.; Nat. Commun. 8, 1843 (2017), Abstract; Full Text
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 616 (2011), Abstract; Full Text
Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non-transformed rat vascular smooth muscle cells: D. Leszczynski et al.e; Am. J. Pathol. 145, 1265 (1994), Abstract;
Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin E1 in HTLV-I-infected T cells: K. Ikeda et al.; J. Biol. Chem. 268, 1174 (1993), Abstract;
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3’,5’-monophosphate: A. Hinko & M.S. Soloff; Endocrinology 132, 126 (1993), Abstract;
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs: Y.-J. Hei et al.; Mol. Pharmacol. 39, 233 (1991), Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer and J.P. Miller; Life Sci. 14, 1019 (1974), Abstract;
The preparation of acylated derivatives of cyclic nucleotides: T. Posternak & G. Weimann; Methods Enzymol. 38, 399 (1974), Abstract;

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