Replaces Prod. #: ALX-480-045
- Cell-permeable PKA activator
- Compound used to study neurogenesis
Dibutyryl-cAMP (DB-cAMP) is a cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (e.g. protein kinase A) and inhibits phosphodiesterases. Used together with other compounds, DB-cAMP increases survival rate and promote differentiation of neural stem/progenitor cells into neurons in vivo. DB-cAMP also has anti-inflammatory properties and can be used to facilitate wound healing. Caution: Due to extra- and intra-cellular esterases, DB-cAMP releases butyrate, which may have distinct biological effects.
Product Details
| Alternative Name: | Dibutyl cyclic AMP sodium salt, N6-2'-O-dibutyryladenosine-3',5'-cyclic monophosphate, DB-cAMP |
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| Formula: | C18H23N5O8P . Na |
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| MW: | 491.4 |
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| Source: | Synthetic. |
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| CAS: | 16980-89-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Identity determined by MS, 1H-NMR, 31P-NMR, and UV spectrum. |
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| Appearance: | White crystalline solid. |
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| Solubility: | Soluble in DMSO (200mM), 96% ethanol (25mM), or water (100mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solution must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods. |
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| Regulatory Status: | RUO - Research Use Only |
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