Replaces Prod. #: ALX-480-007
A cell-permeable cAMP analog which is more resistant to phosphodiesterases than cAMP and which preferentially activates cAMP-dependent protein kinase (PKA). Has increased metabolic stability and membrane permeability comapred with cAMP.
Product Details
| Formula: | C10H10BrN5O6P . Na |
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| MW: | 430.1 |
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| CAS: | 76939-46-3 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR, 31P-NMR, ESI-MS and UV. |
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| Appearance: | White to grey powder |
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| Solubility: | Soluble in water (100mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hormone-induced 14-3-3γ adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells: Y. Aghazadeh et.al; J. Biol. Chem.
287, 15380 (2012),
Application(s): Activation of cAMP-dependent protein kinase (PKA).,
Abstract;
Full Text
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3’,5’-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al.; Biochem. J.
279 , 521 (1991),
Abstract;
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs: Y.-J. Hei et al.; Mol. Pharmacol.
39, 233 (1991),
Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer Jr. & J.P. Miller; Life. Sci.
14, 1019 (1974),
Abstract;
