Replaces Prod. #: BML-EI219
Cyclooxygenase (COX) inhibitor. More selective for PGHS-1 (IC50=17.7µM) over PGHS-2 (IC50>500µM). Clinically useful non-steroidal anti-inflammatory drug. Inhibits PGE2 generation in stimulated rat synovial cells (IC50=0.1µM).
Product Details
| Formula: | C15H13N3O4S |
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| MW: | 331.3 |
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| CAS: | 36322-90-4 |
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| MI: | 14: 7506 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (25mg/ml), 100% ethanol (5mg/ml warm) or chloroform. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Avoid formation of dust and aerosols. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs: O. Laneuville, et al.; J. Pharmacol. Exp. Ther.
271, 927 (1994),
Abstract;
In vitro effect of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidon e (E-5110), a novel nonsteroidal antiinflammatory agent, on generation of some inflammatory mediators: K. Katayama, et al.; Agents Actions
21, 269 (1987),
Abstract;
Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study: T.J. Carty, et al.; Prostaglandins
19, 51 (1980),
Abstract;
