Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1.
Product Details
| Alternative Name: | (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol, 5-Methyl-2-(1-methylethyl)cyclohexanol |
| |
| Formula: | C10H20O |
| |
| MW: | 156.3 |
| |
| CAS: | 2216-51-5 |
| |
| MI: | 14: 5837 |
| |
| RTECS: | OT0700000 |
| |
| Purity: | ≥98% (sum of enantiomers, GC) |
| |
| Identity: | Identity determined by 1H-NMR. |
| |
| Appearance: | Colorless to white crystalline solid. |
| |
| Solubility: | Soluble in 100% ethanol or methanol (100mg/ml). |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Limited shelf life. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Bimodal action of menthol on the transient receptor potential channel TRPA1: Y. Karashima, et al.; J. Neurosci.
27, 9874 (2007),
Abstract;
The menthol receptor TRPM8 is the principal detector of environmental cold: D.M. Bautista, et al.; Nature
448, 204 (2007),
Abstract;
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol.
16, 1591 (2006),
Abstract;
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol.
1, 85 (2005), Review,
Abstract;
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci.
24, 5364 (2004),
Abstract;
Full Text
Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature
416, 52 (2002),
Abstract;
Related Products
