Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis.
Product Details
| Alternative Name: | 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride, A-56620 |
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| Formula: | C20H17F2N3O3 . HCl |
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| MW: | 385.4 . 36.5 |
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| CAS: | 91296-87-6 |
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| MI: | 14: 8370 |
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| Purity: | ≥98% (Assay) |
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| Identity: | Identity determined by IR. |
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| Appearance: | White to yellow crystalline solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Determination of temafloxacin, sarafloxacin, and difloxacin in bulk drug and dosage forms by high-performance liquid chromatography: J.F. Bauer, et al.; Pharm. Res.
7, 1177 (1990),
Abstract;
In vitro activities of A-56619 (difloxacin) and A-56620, two aryl fluoroquinolones: A. Digranes & W.L. Dibb; Chemotherapy
34, 298 (1988),
Abstract;
In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis: O.G. Berlin, et al.; J. Antimicrob. Chemother.
19, 611 (1987),
Abstract;
In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones: P.B. Fernandes, et al.; Antimicrob. Agents Chemother.
29, 201 (1986),
Abstract;
Full Text
Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents: D.T. Chu, et al.; J. Med. Chem.
28, 1558 (1985),
Abstract;
