Originally isolated from Nocardiopsis sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F0F1-ATPase inhibitor.
Product Details
| Formula: | C58H96O21 |
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| MW: | 1129.4 |
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| Source: | Isolated from Amicolatopsis sp. MST-AS5912. |
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| CAS: | 194874-06-1 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Apoptolidin: induction of apoptosis by a natural product: P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl.
45, 872 (2006),
Abstract;
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues: P.A. Wender, et al.; Org. Lett.
8, 589 (2006),
Abstract;
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase: A.R. Salomon, et al.; Chem. Biol.
8, 71 (2001),
Abstract;
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase: A.R. Salomon, et al.; PNAS
97, 14766 (2000),
Abstract;
Full Text
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp: J.W. Kim, et al.; J. Antibiot. (Tokyo)
50, 6628 (1997),
Abstract;
