Antitumor antibiotic. Powerful, selective inhibitor of nucleic acid synthesis in vitro. Potent inhibitor of hypoxia-inducible factor 1 (HIF-1) DNA binding activity. Induces apoptosis. Displays antibacterial, antifungal and antiviral activities.
Product Details
| Alternative Name: | Quinomycin A |
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| Formula: | C51H64N12O12S2 |
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| MW: | 1101.3 |
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| Source: | Isolated from Streptomyces echinatus (DSM 40013) |
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| CAS: | 512-64-1 |
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| MI: | 14: 3497 |
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| RTECS: | JW5250000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, dimethyl formamide or DMSO; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
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Identity of levomycin and quinomycin A (echimomycin): K. Katagiri, et al.; J. Antibiot.
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A “quinoxaline antibiotic” similar to the triostins, q.v.: I. Kuroya, et al.; J. Antibiot. 14A, 324 (1961),
