Antitumor antibiotic. Powerful, selective inhibitor of nucleic acid synthesis in vitro. Potent inhibitor of hypoxia-inducible factor 1 (HIF-1) DNA binding activity. Induces apoptosis. Displays antibacterial, antifungal and antiviral activities.
Product Details
| Alternative Name: | Quinomycin A |
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| Formula: | C51H64N12O12S2 |
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| MW: | 1101.3 |
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| Source: | Isolated from Streptomyces echinatus (DSM 40013) |
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| CAS: | 512-64-1 |
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| MI: | 14: 3497 |
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| RTECS: | JW5250000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, dimethyl formamide or DMSO; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Constitutive HIF-1 activity in malignant melanoma: S. Kuphal, et al.; Eur. J. Cancer
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Abstract;
Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy: R.A. Cairns, et al.; PNAS
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Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway: J.Y. Park, et al.; Int. J. Biochem. Cell Biol.
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Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway: J.Y. Park, et al.; Pharmacol. Res.
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Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates: L.G. May, et al.; Nucl. Acids Res.
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Energetics of echinomycin binding to DNA: F. Leng, et al.; Nucl. Acids Res.
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Localized chemical reactivity in DNA associated with the sequence-specific bisintercalation of echinomycin: C. Bailly, et al.; Biochem. J.
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Interaction of echinomycin with An.Tn. and (AT)n regions flanking its CG binding site: K. Waterloh & K.R. Fox; Nucl. Acids Res.
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Abstract;
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Effect of echinomycin on DNA methylation: R.L. Adams & A. Rinaldi; FEBS Lett.
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Abstract;
Kinetic evidence that echinomycin migrates between potential DNA binding sites: K.R. Fox & M.J. Waring; Nucl. Acids Res.
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Echinomycin binding sites on DNA: M.M. Van Dyke & P.B. Dervan; Science
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Abstract;
Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences: C.M. Low, et al.; Nucl. Acids Res.
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Kinetics of the interaction between echinomycin and deoxyribonucleic acid: K.R. Fox, et al.; Biochemistry
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Abstract;
Bifunctional intercalation and sequence specificity in the binding of quinomycin and triostin antibiotics to deoxyribonucleic acid: J.S. Lee & M.J. Waring; Biochem. J.
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Abstract;
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The binding of echinomycin to deoxyribonucleic acid: S.P. Wakelin & M.J. Waring; Biochem. J.
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The mode of action of quinoxaline antibiotics. Interaction of quinomycin A with deoxyribonucleic acid: K. Sato, et al.; J. Antibiot.
20, 270 (1967),
Abstract;
Identity of levomycin and quinomycin A (echimomycin): K. Katagiri, et al.; J. Antibiot.
15, 273 (1962),
Abstract;
A “quinoxaline antibiotic” similar to the triostins, q.v.: I. Kuroya, et al.; J. Antibiot. 14A, 324 (1961),
