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Concanamycin C

V-ATPase inhibitor



ALX-380-099-C500	500 µg	2,711.00 USD
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Antibiotic. Inhibits vacuolar-type H⁺-ATPase. Potential antiosteoporotic agent. Shows antiviral and immunosuppressive activity. Active against fungi and yeasts.

Product Specification

Formula:	C₄₅H₇₄O₁₃

MW:	823.1

Source:	Isolated from Streptomyces sp.

CAS:	81552-34-3

RTECS:	GK6887000

Purity:	≥96% (HPLC)

Identity:	Determined by ¹H-NMR.

Appearance:	White to off-white solid.

Solubility:	Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.

Shipping:	Ambient

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Handling:	After reconstitution protect from light at -20°C.

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Product Literature References

Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes: S. Drose, et al.; Biochemistry 40, 2816 (2001), Abstract;

Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa: E.J. Bowman, et al.; J. Biol. Chem. 275, 167 (2000), Abstract;

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993), Abstract;

Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984), Abstract;

Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 35, 1618 (1982), Abstract;