Antibiotic. Inhibits vacuolar-type H+-ATPase. Potential antiosteoporotic agent. Shows antiviral and immunosuppressive activity. Active against fungi and yeasts.
Product Details
| Formula: | C45H74O13 |
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| MW: | 823.1 |
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| Source: | Isolated from Streptomyces sp. |
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| CAS: | 81552-34-3 |
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| RTECS: | GK6887000 |
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| Purity: | ≥96% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes: S. Drose, et al.; Biochemistry
40, 2816 (2001),
Abstract;
Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa: E.J. Bowman, et al.; J. Biol. Chem.
275, 167 (2000),
Abstract;
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry
32, 3902 (1993),
Abstract;
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo)
37, 1333 (1984),
Abstract;
Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo)
35, 1618 (1982),
Abstract;
