- Highly pure Ganglioside GQ1b isolated from bovine brain
- Used for the differentiation of a variety of cells
Gangliosides consist of a ceramide moiety, an oligosaccharide head group, and one or more sialic acids. They are involved in a variety of cellular functions acting as cell adhesion receptors and immunological receptors via the binding of lectins; contributing to cell differentiation, cell signaling, and oncogenesis; participating in myelin stability and nerve regeneration; and operating as an entry point for toxins and viruses. Ganglioside GQ1b consists of a tetra-saccharide core with two sialic acid on the internal galactose and two sialic acid on the non-reducing terminal galactose. Ganglioside GQ1b promotes the differentiation of human neuroblastoma cells, murine embryonic stem cells via the activation of the ERK1/2 pathway, and murine keratinocytes via phosphoinositide turnover.
Product Details
| Alternative Name: | GQ1b . 4Na (bovine brain), Tetrasialoganglioside GQ1b . 4Na (bovine brain) |
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| Sequence: | [II3(Neu5Ac)2, IV3(Neu5Ac)2GgOse4Cer] [[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1’)-Cer] |
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| Formula: | C106H178N6O55 . 4Na |
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| MW: | 2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid) |
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| Source: | Bovine brain |
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| CAS: | 68652-37-9 |
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| Purity: | ≥98% (HPTLC) |
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| Appearance: | Lyophilized. |
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| Solubility: | Soluble in biological buffers, DMSO, or water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | If stored at -20°C the product is stable for at least 2 years. After reconstitution the solution should be stored at -20°C and is stable for at least 1 year. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ganglioside GQ1b ameliorates cognitive impairments in an Alzheimer's disease mouse model, and causes reduction of amyloid precursor protein: M. Shin, et al.; Sci. Rep.
9, 8512 (2019),
Abstract;
Full Text
Ganglioside GQ1b ameliorates cognitive impairments in an Alzheimer’s disease mouse model, and causes reduction of amyloid precursor protein: M.K. Shin, et al.; Sci. Rep.
9, 8512 (2019),
Abstract;
Full Text
GQ1b, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in the two neuroblastoma cell lines: S. Tsuji, et al.; J. Biochem.
94, 303 (1983),
Abstract;
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