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Ganglioside GT1b . trisodium salt (bovine brain)

Brain ganglioside
ALX-302-011-M001 1 mg 142.00 USD
ALX-302-011-M005 5 mg 452.00 USD
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  • Highly pure Ganglioside GQ1b isolated from bovine brain
  • Used for the differentiation of a variety of cells
Gangliosides consist of a ceramide moiety, an oligosaccharide head group, and one or more sialic acids. They are involved in a variety of cellular functions acting as cell adhesion receptors and immunological receptors via the binding of lectins; contributing to cell differentiation, cell signaling, and oncogenesis; participating in myelin stability and nerve regeneration; and operating as an entry point for toxins and viruses. Ganglioside GT1b consists of a tetra-saccharide core with two sialic acid on the internal galactose and an extra sialic acid on the non-reducing terminal galactose. Ganglioside GT1b prevents neurotoxicity of glutamate on neuronal cells and binds to the neurotoxins Botulinum Toxin serotype A (BTxA), BTxA heavy chain, and Tetanus Toxin with respective IC50 values of 11, 0.74, and 7.2 µM. Treatment of human PBMC with Ganglioside GT1b is associated with a decrease in IgA, IgG, IgM, IL-6, and IL-10 levels.

Product Details

Alternative Name:GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain)
Sequence:[II3(Neu5Ac)2, IV3(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer]
Formula:C95H162N5O47 . 3Na
MW:2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)
Source:Bovine brain
Purity:≥98% (TLC)
Identity:Confirmed by MS.
Appearance:White solid.
Solubility:Soluble in chloroform/methanol/DI water, 2:1:0.1; forms micellar solution in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA: D.C. Rupp, et al.; Clin. Cosmet. Investig. Dermatol. 16, 581 (2023), Abstract;
Anti-inflammatory role of GM1 and other gangliosides on microglia: D. Galleguillos, et al.; J. Neuroinflammation 19, 9 (2022), Abstract; Full Text
Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay: N.G. James, et al.; Sci. Rep. 11, 7832 (2021), Abstract; Full Text
A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice: Q. Guo, et al.; J. Control Release 320, 347 (2020), Abstract;
Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol: B.J. Pavlik, et al.; Sci. Rep. 6, 23707 (2016), Abstract; Full Text
GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons: E.S. Chung, et al.; BMC Neurosci. 11, 74 (2010), Abstract;
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex: M. Favaron, et al.; PNAS 85, 7351 (1988), Abstract;

General Literature References

Botulinum neurotoxin: a marvel of protein design: M. Montal; Annu. Rev. Biochem. 79, 591 (2010), Abstract; Full Text

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