Prevents neurotoxicity of glutamate on neuronal cells.
Product Details
| Alternative Name: | GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain) |
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| Sequence: | [II3(Neu5Ac)2, IV3(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer] |
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| Formula: | C95H162N5O47 . 3Na |
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| MW: | 2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid) |
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| CAS: | 59247-13-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in chloroform/methanol/DI water, 2:1:0.1; forms micellar solution in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons: E.S. Chung, et al.; BMC Neurosci.
11, 74 (2010),
Abstract;
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex: M. Favaron, et al.; PNAS
85, 7351 (1988),
Abstract;
General Literature References
Botulinum neurotoxin: a marvel of protein design: M. Montal; Annu. Rev. Biochem.
79, 591 (2010),
Abstract;
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